SMART Bandage for monitoring wound perfusion

 

The overall goal of this project aims to convert a bulky and high-cost optical sensing system used in a scientific research lab into an ultra-compact portable optical sensing device that can report wound healing in real-life clinical setting. Our central hypothesis is that by integrating state-of-art nanophotonic membrane device technology, robust fluorescent and surface enhanced Raman scattering (SERS) signals of dye and metal nanoparticles, and smart shape memory polymer materials, the interdisciplinary team can develop a cost-effective and highly flexible non-invasive optical SMART (Sensing, Monitoring, And Release of Therapeutics) bandage system which can monitor and cure diseases in real time. In this project, we will demonstrate an application of this SMART bandage in chemical sensing microenvironment of complex wounds (pH) and quantitatively reports tissue perfusion for optimizing wound healing.

With the proposed SMART bandage system, we can provide caregivers with a continuous, quantitative read-out of treatment response and wound healing. The system developed here should lead to an even broader area of applications, including wearable healthcare networks, Internet of things (IoT), biomedical sensing, and bio-integrated, bio-implantable electronic systems for targeted cell sensing, imaging, and controlled/targeted therapeutic release/curing of vulnerable tissues.

Weidong Zhou, Ph.D. UTA
Professor – Electrical Engineering
wzhou@uta.edu//817-272-1227//Biography
Co-PIs:
Yaowu Hao, Ph.D. UTA
Jie Zheng, Ph.D. UTD
Walter Voit, Ph.D. UTD
F. Jon Senkowsky, MD, FACS, THR

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