Single-walled Carbon Nanotube-based Near-Infrared Optical Glucose Sensor for In Vivo Continuous Glucose Monitoring

 

Diabetes is a metabolic disease characterized by high blood glucose levels and is one of the most challenging global health problems with high human, social, and economic costs. Persistent or frequent hyperglycemia (high blood glucose) leads to serious complications, including cardiovascular disease, kidney disease, eye disease, and nervous system disease. To achieve their target glycemic levels, diabetic patients rely on self-monitoring of blood glucose (SMBG); they measure the instantaneous levels of blood glucose using a finger-prick glucose meter (typically, 3 to 10 times daily). However, even patients with well-controlled diabetes who measure blood glucose several times daily often experience hyperglycemia after meals and hypoglycemia (low blood glucose) at night. Because the level of blood glucose fluctuates throughout the day, effective management of diabetes requires real-time monitoring of blood glucose (less than 10 minutes per measurement), or continuous glucose monitoring (CGM). Current CGM technologies, however, do not meet the demand. State-of-the-art commercial CGM devices have lifetimes of only 5 to 7 days and require frequent recalibration. Other emerging technologies are in development but still fall short. To overcome this challenge, we propose to develop a fully implantable, completely passive, patient-friendly single-walled carbon nanotube (SWNT)-based near-infrared (NIR) optical glucose sensor for long-term continuous glucose monitoring (CGM).

Kyungsuk Yum, Ph.D. UTA
Assistant Professor – Materials Science and Engineering
kyum@uta.edu//817-272-2398//Biography
Co-PI:
A. Dean Sherry, Ph.D. UTD

 

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