Texas MRC Research Projects

 

The purpose of this project is to develop and market a glass-based Neuro-Sensor as a high throughput drug discovery tool. This transparent device directs the growth of nerve cell projections (i.e., axons or dendrites) through mesa-scale microfluidic channels. Electrical impedance sensors through microelectrodes will be incorporated into the device to monitor and quantify the biological response of axon growth when neurons are exposed to a variety of chemicals.  The Neuro-Sensor here proposed has many dramatic advantages over traditional assays such as simple operation, rapid detection, long-term stability of chemically inert substrates, low cost, and high sensitivity. The product will not only be applicable to nerve regeneration research, but also to many micro-level cellular experimental applications including cell migration, wound healing and blood flow.

Principal Investigator:

Richard Billo, Ph.D., UTA
Professor-College of Engineering, Associate Dean of Engineering for Research-College of Engineering
richard.billo@uta.edu // (817) 272-2708 // Biography (more…)

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One in three older adults fall each year causing serious, life threatening injuries, increasing caregiver burden, and health care costs. The majority of research focused on understanding what causes falls in older adults considers the impact of age-related visual, motor and cognitive impairments. Recent studies have shown that individuals with hearing loss may be at greater risk of falls than individuals without hearing loss. Importantly, hearing loss affects more than half of adults over the age of 65 and startlingly, of those who could benefit from a hearing aid (thus potentially reducing falls), 2/3 decline or fail to seek treatment. Overall, despite the acknowledged association between hearing loss and falls, very few systematic studies have adequately defined this relationship. (more…)

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Prostate cancer is the second leading cause of malignancy-related mortality in males. Prostate cancer cells spread to liver, lungs, and especially bone via the blood stream and form secondary tumors in these organs. Bone metastases are incurable and a major complication of prostate cancer patients. Cancer cell motility towards increasing concentrations of certain chemicals plays an important role in metastases. Several chemicals such as chemokines and growth factors are believed to influence the migration of prostate cancer cells. Despite improvement in clinical response rates with newly developed targeted multi-kinase inhibitors, death due to metastases remain major impediments to its cure. With a focus on the development of new inhibitors, particularly, RLIP76 blockade has been shown highly effective. The findings are potentially of major clinical significance because they promise a unique, highly effective and functionally cancer-specific targeted therapy.  (more…)

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Prototype of the e-strip, which uses an IC chip developed at UTD, has been created for the Diagnostics of Diabetes. This salivary test checks a number of diabetes markers, is non-invasive, painless, and inexpensive. Researchers are testing effectiveness of the salivary test compared to the standard blood test. (more…)

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